Ankur Arora Murder Case is a medical thriller drama that is based on a real-life incident. Dr. V. Asthana (Kay Kay Menon) is the Chief Surgeon of the Shekhawat General Hospital. When an eight-year-old boy Ankur Arora (Vishesh Tiwari) dies due to Dr. Asthana’s medical negligence, he destroys all the evidence against him. However, Ankur’s mother Nandita Arora (Tisca Chopra) is helped by the young medical intern, Dr. Romesh Sharma (Arjun Mathur), and the two set out to fight for justice.