Anwar Ka Ajab Kissa is a simple comedy-drama that narrates the journey of Anwar (Nawazuddin Siddiqui), a detective who works in a small detective agency called ‘Inner Eye’. His job involves solving cases where he has to follow people and spy on their personal lives which often gets him into troublesome and comic situations. Despite taking the help of his pet dog, his amateurish way of handling cases reflects his personality which is also the reason for his wife Ayesha (Niharika Singh) leaving him. How he tries to win back his wife and become a better professional form the remaining part of the story.