Damadamm! is a romantic comedy-drama that revolves around Sameer (Himesh Reshammiya), a scriptwriter for Bollywood films. He works with his girlfriend Shikha (Purbi Joshi), who is over-possessive about him and suspects him all the time. Sameer doesn’t know how to get rid of Shikha’s suspicions. One day Shikha gets invited to her relative’s wedding and she leaves for a few weeks. Sameer starts enjoying his newly found freedom, but how long will it last? Will Shikha come to know what he has been doing in her absence or will she stop suspecting him forever?