Despatch is a story that revolves around a senior crime journalist Joy Bag (Manoj Bajpayee) who works at a newspaper called 'Despatch'. The film focuses on peoples interest shifting from news print to digital newsrooms while given the consumption of news on the move. To turn around things for his newspaper, Joy looking for something big while his personal life is undergoing a turmoil where he is in love with Prerna (Arrchita Agarwaal) and at the same time seeking a divorce from his wife Shweta (Shahana Goswami). Amidst all this, Joy gets a whiff of a story about a scam involving big names which holds the potential to rock the country. What will he do next?