Do Deewane Seher Mein is an urban romantic drama set in Mumbai that follows the story of Roshni (Mrunal Thakur) and Shashank Sharma (Siddhant Chaturvedi), who are dealing with their inner imperfections. Roshni, who works in the corporate world and is insecure about her looks, and Shashank (Siddhant Chaturvedi), who works as a salesman and is often held back by a speech impediment. Shashank and Roshni meet at an arranged marriage setup along with their parents, which is rejected, but the latter eventually falls in love with not-so-perfect Shashank. The dynamics between them change as they start their courtship. Through love and humour, they help each other embrace their imperfections and discover that being real is more beautiful than being perfect.