Girls Will Be Girls is a coming-of-age conventional romantic drama set in the 90s in the hill station of Mussoorie, Uttarakhand where a teenage girl named Mira Kishore (Preeti Panigrahi) studies in a school in class 12 and has become the first girl of the school to be elected as the head prefect. She befriends her classmate Srinivas (Kesav Binoy Kiron), who has relocated from Hong Kong. Both get attracted to each other as he is introduced to Mira's mother Anila (Kani Kusruti) who takes a liking for him whenever he visits her house. Anila and Srinivas's closeness makes Mira jealous. As Mira explores different facets of youth along with Srinivas she gets into the bad books of certain male students and her school principal, Bansal ma'am (Devika Shahani). What happens next forms the rest of the film.