Grand Masti is an adult romantic comedy and the sequel to the 2004 film Masti that revolves around three friends Amar (Riteish Deshmukh), Meet (Vivek Oberoi) and Prem (Aftab Shivdasani), who are unhappy and unsatisfied with their marriage. They receive an invite from their college to attend the college reunion. They see the college reunion as a chance to finally have some fun. However, they end up in trouble when their ex-classmate blackmails them to kill the principal to fulfill his revenge. How will Amar, Meet and Prem get out of this mess and will their wives come to know about their intentions?