Humshakals is a romantic comedy-drama that follows the story of two best friends – Ashok (Saif Ali Khan) and Kumar (Riteish Deshmukh), who end up in the mental asylum because of Ashok’s uncle, Kunwar Amarnath Singh’s (Ram Kapoor) foul play, who wishes to inherit Ashok’s wealth. When the doctor in the mental asylum realizes that the two are sane, she decides to release them. However, she accidentally releases the lookalikes of Ashok and Kumar, which causes a lot of confusion. The chaos ensues when the third set of lookalikes of Ashok and Kumar are brought in by Kunwar Amarnath Singh, who is still determined to get all the money.