I, Me Aur Main is a romance drama. The movie revolves around Ishaan (John Abraham), a good-looking, smart, self-centred and coquettish man from Mumbai. Ishaan lives with his girlfriend Anushka (Chitrangada Singh) and takes her for granted. Anushka kicks Ishaan out of her house for being irresponsible. He then meets his new neighbour Gauri (Prachi Desai) and starts falling for her. Soon Ishaan realizes his mistake and understands the importance of taking responsibility.