Ishq-E-Nadaan is an anthology that showcases three stories set against the backdrop of Mumbai. The first is that of a widower and single father, Ashutosh (Mohit Raina) who works in a hotel where he meets Ramona (Lara Dutta), an upcoming entrepreneur. Ashutosh is attracted towards Ramona after a few interactions but everything changes for the former when the latter reveals that she is leading a complex life and expecting something else from it. The other story is that of a middle-aged single mother, Charulatha (Neena Gupta) who visits Mumbai to meet her daughter’s family where she befriends a film director Subhash Kapoor (Kanwaljit Singh) and confides in him. The third story is that of Siya (Shriya Pilgaonkar) who is pregnant after breaking off with her husband Raghav (Mrinal Dutt) when Piyush (Suhail Nayyar) enters her life to take care of her emotionally. The remaining plot is about how do the three couples’ relationship evolves and make a new beginning with a different outlook.