Kaalakaandi is a dark comedy-drama. The movie follows three different plots. Rileen (Saif Ali Khan), a teetotaller, learns that he is suffering from stomach cancer and has only one month to live, so he decides to live life to the fullest by smoking and taking hard drugs. Tara (Sobhita Dhulipala), a young girl who wishes to pursue higher studies in the US, gets involved in a hit and run and seeks redemption. Two goons, Mafia (Deepak Dobriyal) and Rahmat (Vijay Raaz) wish to extract money from their boss Raza (Asif Basra) but they must decide if they can trust each other.