Karam is a crime thriller drama that revolves around a contract killer named John (John Abraham) who is assigned to kill someone. While he carries out the hit, the family of the victim arrives at the place where the hit was planned, and John has to kill everyone. The event traumatizes John and he becomes guilt-ridden. He then decides to mend his ways and leave the life of crime. However, when Shalini (Priyanka Chopra), John’s wife, gets kidnapped he has to get back to his old ways one last time to protect her. Is he wise enough to do that or his decision will get him in some danger?