Meenaxi: A Tale of Three Cities is a romantic drama. The movie follows the story of a writer from Hyderabad, Nawab (Raghuvir Yadav). Nawab is a novelist who is suffering from writer’s block, and it has been five years since he has got any inspiration for his novel. However, things take a turn for him when he comes across a young and attractive woman named Meenaxi (Tabu), whose individualistic personality impresses Nawab. He is happy to realize that he has finally found a muse. Nawab starts imagining her in three different personae, each belonging to a different city – Hyderabad, Jaisalmer, and Prague. Though Meenaxi is critical of his story, she likes some parts of it. Will Nawab finally be able to complete his next novel, with little to no support from his muse?