My Brother… Nikhil is a sports drama. The film is set in Goa between 1984 and 1994 when AIDS awareness was low and the patients were treated as criminals. The movie revolves around a man named Nikhil (Sanjay Suri), a young bright swimmer, whose life takes a turn when he gets diagnosed with HIV. His life falls apart, he is removed from the swimming team and his family throws him out of the house. During the difficult times, he finds support from his sister Anamika (Juhi Chawla) and friend Nigel (Purab Kohli). Nikhil is forcefully arrested and kept in isolation, as the Goa Public Health Act allows the government to isolate HIV-positive people. Nigel and Anamika face the threats of the local public but succeed in securing the release of Nikhil. However, will Nikhil get the acceptance of his parents and society?