Nautanki Saala! is a romantic comedy drama based upon the 2003 French comedy film Après Vous. The movie revolves around Ram Parmar (Ayushmann Khurrana), a successful theatre artist. One day on his way back home, Ram witnesses Mandar Lele (Kunaal Roy Kapur) attempting to commit suicide and saves him. Mandar is devastated because of his break-up with Nandini (Pooja Salvi). Ram promises to help Mandar out by trying to meet Nandini and make her understand his friends love for her but instead Ram falls for Nandini’s charm and finds himself in a bigger mess as he cannot disclose the same to Mandar. What does Ram do now to solve all the three’s problems?