Pyaar Ke Side Effects is a romantic comedy-drama. The movie revolves around Siddharth aka Sid (Rahul Bose), a commitment-phobic DJ, who is in a relationship with Trisha Mallik (Mallika Sherawat). Trisha wants to marry Sid, and in a fit to lose her Sid agrees to her wish. However, things take a turn when Sid meets Veera Bhadra Mallik (Sharat Saxena), Trisha’s father, who disapproves of Sid. Will Sid manage to make Veera like him or end up losing Trisha?