Sharmajee Ki Beti is a family comedy-drama that revolves around the life of three 'Sharma's - Jyoti Sharma (Sakshi Tanwar), Kiran Sharma (Divya Dutta), and Tanvi Sharma (Saiyami Kher) who stay in Mumbai. Jyoti Sharma is a teacher married to Sudhir Sharma (Sharib Hashmi) and has a 14-year-old daughter, Swati (Vanshika Taparia) who hasn't yet got her period. Despite all her efforts, Jyoti doesn't get quality time to spend with her daughter but gets all the support from her working husband. Kiran Sharma (Divya Dutta) is married to Vinod Sharma (Pravin Dabas) and has a 14-year-old daughter Gurveen (Arista Mehta) who is Swati's classmate. Kiran is a housewife who discovers her husband is having an affair and decides to move out to start her event programs. Tanvi Sharma is a young aspiring cricketer waiting to play for India. She is in love with Rohan (Ravjeet Singh) who is on the verge of playing the lead role in a film. Rohan urges Tanvi to quit cricket so he can become the sole bread earner after marriage but the latter chooses her game.