Sheesha is a psychological romantic thriller drama. The movie revolves around a successful businesswoman, Sia Malhotra (Neha Dhupia), based in Bangkok. She lives a wealthy lifestyle with her twin sister, Ria (also played by Neha Dhupia), who suffers from a neurological disorder and is deaf and dumb. Sia marries her boyfriend Raj (Sonu Sood). She leaves Ria with Raj to go on a business trip to the United States. Things take a turn when she returns, as she is suspected to have murdered a Caucasian, Diana. She faces further trauma when she realizes Ria is preying on her husband and Raj refuses to believe Sia. Will Sia be able to make Raj believe her and save him from her sister?