Table No. 21 is a crime thriller drama that revolves around a young married couple, Vivaan (Rajeev Khandelwal) and Siya Agasthi (Tina Desai). The two decide to enter a game show called ‘Table No. 21’ to win the handsome amount of INR 210 million as a prize. The rules of the game are easy, the couple must truthfully answer eight personal questions to be asked to them and complete the task related to the question. At first, the questions and the tasks in the game seem easy, but as the game progresses, the tasks turn horrific and become a dangerous game of survival for the couple.