The Lady Killer is a crime, thriller, suspense drama set in the small town of Nainital in Uttarakhand state where a chemist Rajendra Joshi (Arjun Kapoor) who runs a medical shop goes to meet a richman in his old mansion to deliver oxygen cylinders where he meets his young wife Jansey Burman (Bhumi Pednekar) and has an affair with her. Indulging with the wife Rajendra gradually realises that everything isn't well while the wife is hiding a secret from him that may spell trouble. What happens next?