Tipppsy: Jab Ho Gaye Talli is a suspense thriller that depicts the story of a girl gang including Pony (Alankrita Sahai), Yami (Kainaat Arora), Tanya (Natasha Suri), Iris (Nazia Hussain), and Selene (Sonia Birje), who are on a vacation spree in Goa to enjoy a bachelorette party. Their fun is short-lived when they get trapped in the web of rape and murder as they become suspects for investigation officer, Jacob (Deepak Tijori).