Tumse Na Ho Payega is a comedy drama about Gaurav Shukla (Ishwak Singh) who lives with his mother and works in a software company. After serving five years in the company, he decides to call it quits and start his own startup along with his friends – Sharad Malhotra (Gaurav Pandey), Hardik Vaghela (Gurpreet Saini) and Devika (Mahima Makwana). Their startup grows slowly and steadily and soon reaches a stage when investors start knocking at their doors. On behest of the investors, they compromise on their business strategy which leads to a shut down. Gaurav and Sharad again decide to start their business from scratch retaining its core values. Do they succeed?