BhaiyyaJi is the story of Ram Charan (Manoj Bajpayee), a wealthy man who resides in a small town in Bihar with his mother (Bhagirathi Bai) and brother Vedant (Akash Makhija). Ram Charan is all set to get married to Mitali (Zoya Hussain) when he gets to hear the terrible news of his brother Vedant dying in an accident in Delhi after getting a call from a Delhi cop, Magan (Vipin Sharma). On reaching Delhi and claiming his brother’s body Ram Charan refuses to buy Magan’s story as he knows that Vedant was not an alcoholic. He is proved right when he meets Vedant's friends, who confirm that Vedant was killed by Abhimanyu (Jatin Goswami), son of a landlord, Chandrabhan Singh (Suvinder Vicky). Ram Charan breaks his old promise and is compelled to take up arms again and fight Abhimanyu and Chandrabhan Singh. What happens next forms the rest of the film.