Ek Chalis Ki Last Local is an adventure comedy thriller. The movie revolves around Nilesh Rastogi (Abhay Deol), who misses the last local train at 1:40 am at Kurla Station. He works in a call center and when he misses the last train from Kurla to Vikhroli, he strolls outside the station for a rickshaw, where he bumps into a young beautiful woman in distress, Madhu (Neha Dhupia), who also wanted to go to Vikhroli. As the rickshaws were on strike, the two decided to walk to the next rickshaw stand. However, they didn’t know that this encounter would lead to weird and unnatural events that would change their lives forever.