Game is a crime-action drama. Four strangers, Neil Menon (Abhishek Bachchan) – a casino owner in Turkey, Vikram Kapoor (Jimmy Sheirgill) – an Indian actor, OP Ramsay (Boman Irani) – a politician in Thailand and Tisha Khanna (Shahana Goswami) – a crime journalist in the US, are invited by a billionaire named Kabir Malhotra (Anupam Kher) on his private island in Greece. All four were somehow related to Kabir’s daughter, Maya (Sarah-Jane Dias), who recently got murdered. Kabir accuses them of the murder, however, things take a turn when he gets shot.