I Want To Talk is an enduring tale of Arjun Sen (Abhishek Bachchan), a fish fry-loving Bengali NRI living in the USA who has been busy with his job and as a result is unable to spend much time with his wife and daughter, Reya (Pearle Dey/Ahilya Bamroo). At the peak of his career, Arjun is diagnosed with an advanced stage of Laryngeal cancer and is given only 100 days to live, but his meeting with Dr. Deb (Jayant Kriplani) adds a new chapter to his life. His illness helps him get closer to his daughter but is unable to talk his heart out despite his estranged relationship with his wife. Through his constant bickers with his daughter, wife, doctors and even God, Arjun always looks at the brighter side of life, no matter what life throws at him!