Kalki 2898 AD is a sci-fi adventure thriller set in post-apocalyptic times, partially based on the Kalki purana and Indian mythology. Set in Kashi, which was once considered a city of wisdom and divinity, has turned into a barren piece of rotten land that is ruled by a 'complex', a giant futuristic building created by Supreme Yaskin (Kamal Haasan). Yaskin is on a mission to experiment and find a woman who can keep a foetus in her womb for at least 150 days. Sum 80 (Deepika Padukone) is the woman who is five months pregnant, but knowing that her life is in danger, she escapes from the clutches of Yaskin and his commander (Saswata Chatterjee) to make it to the magical city of 'Shambhala'. ‘Shambala’ is a forbidden place where Supreme Yaskin's army hasn't reached or, in other words, caused destruction. It is believed that Sum 80 is expected to give birth to Lord Vishnu avatar, Kalki who is expected to reset the world in order and bring back the very things that make it worth living. The moment commander knows about Sum 80’s escape, he hires Bhairava (Prabhas) a nonchalant ruffian, to eliminate her for 5 million units. To protect Sum 80 and overlook the birth of Kalki, Ashwatthama (Amitabh Bachchan), who was cursed by Lord Krishna, is brought in. Will Bhairava get the better of Ashwatthama or will the latter succeed in protecting his next avatar, Kalki?