Kho Gaye Hum Kahan is an urban story set in Mumbai where three best friends namely Imaad Ali (Siddhant Chaturvedi), Ahana Singh (Ananya Panday) and Neil Pereira (Adarsh Gourav) stay in an apartment. Imaad is a stand-up comedian and a Tinder addict who is attracted to an older woman. Ahana works as a market planner for a multi-national and is in a relationship with her commitment-phobic boyfriend (Rohan Gurbaxani). Neil is a gym rat who has his influencer girlfriend (Anya Singh) with a million and growing head count. The three are mostly addicted to their social media handles trying to figure out ways to get out of their middle-class-life rut. Despite staying together most of the time the three have their share of trauma and insecurities to deal with. To get out of the rut they seek validation on social media!