Krazzy 4 is a black comedy thriller film. The story revolves around four men with intellectual disabilities – Raja (Arshad Warsi), Gangadhar (Rajpal Yadav), Dr. Mukherjee (Irrfan Khan), and Dabboo (Suresh Menon). Raja has Intermittent Explosive Disorder that makes him lose his temper, Gangadhar has schizophrenia, Dr. Mukherjee is diagnosed with obsessive-compulsive disorder and Dabboo suffers from Selective Mutism. They all are being treated by Dr. Sonali (Juhi Chawla). One day, Dr. Sonali takes the four of them to see a cricket match between India and England. However, she gets kidnapped. The four try to find her and take the help of a TV reporter Shikha (Dia Mirza). Will they find Dr. Sonali and protect her from the kidnappers?