Operation Mayfair is a psychological crime thriller that revolves around a detective Amar Singh (Jimmy Shergill) who after failing to catch a serial killer years back decides to quit his job and ends up joining the Oxford University as a professor of architecture. A case of unsolved murder mysteries that take place in the town comes knocking at Amar`s door after a hiatus of a few years. Amar is called upon to solve the series of murders as the killer returns leaving no clue behind. Amar decides to return and resolve the case once and for all.