Shaadi Ke Side Effects is a romantic comedy-drama that revolves around a young happily married couple – Sid (Farhan Akhtar) and Trisha (Vidya Balan). Things take a turn for the couple when Trisha gets pregnant. The two find themselves struggling with the challenges of parenthood even after the birth of their baby and their relationship becomes more and more complicated for them. The new responsibilities force them to change their carefree lifestyle and become more committed to the family. They struggle and complain initially but eventually understand the importance of family.