Sikandar Ka Muqaddar is a crime thriller set against the backdrop of 2009 Mumbai, where diamonds worth 60 crores are stolen at the 10th DFFI Exhibition held at the NICSO Exhibition Centre, Mumbai. Investigating Officer Jaswinder Singh (Jimmy Shergill) quickly narrows his list of suspects to three—Mangesh Desai (Rajiv Mehta), a veteran employee at the jewellery store; Kamini Singh (Tamannaah Bhatia), his colleague; and Sikandar Sharma (Avinash Tiwary), a computer techie who hurriedly left the scene after the alarm is triggered. Despite not proven guilty Sikandar’s entire life turns upside down when he realizes that fate has different plans for him. He marries Kamini, a single mother hoping that things might turn around as he shifts base to Abu Dhabi. 15 years later in 2024, Jaswinder is no longer the decorated officer that he once was but keeps a tab on Sikandar who returns from Abu Dhabi, UAE to India, they decide to meet to settle past scores. What happens next forms the rest of the plot.