Single Salma is the story of a 33-year-old woman named Salma Rizvi (Huma Qureshi), who works in the municipal department of Lucknow. Salma lives with her father (Kanwaljit Singh), mother and brother Subhan (Sachin Kavetham) who are completely dependent on her. She tries her best to pay back the dues for her ancestral house and then and now is pressurised to get married. After rejecting many alliances, she finally meets Sikandar Khan (Shreyas Talpade), a semi-literate man who runs an apparel shop in Lucknow. Salma is impressed by his humility and agrees to marry but suddenly has to go to London for two months as part of the Lucknow Smart City project. Salma is discouraged by her family to go to London but Sikandar encourages her to take the plunge. In London, Salma meets Meet Singh (Sunny Singh) and before she realizes, she is attracted to him. What happens next forms the rest of the story.