Tamacha is an action drama. The movie follows the story of two childhood friends - Raju (Jeetendra) and Vicky (Rajnikanth), who go to the same school and excel in sports and studies. Things go great for the two friends, until a series of tragedies strike in their lives, during which, Raju’s father loses his eyesight and Vicky’s mother dies giving birth to his brother, while his father is on a run from police. Raju grows up and becomes an honest cop, Inspector Rajiv, while Vicky grows up and becomes a notorious gangster, Vikram. Being on the opposite sides of the law, the two best friends now become sworn enemies. It is to be found, who becomes the winner of this cat and mouse race?