Zindagi Tumse is a social family drama about a middle-aged woman Mamta (Sadhana Singh) for whom life changes after her husband passes away. Mamta raises her children single-handedly until they grow up, get married, and have their own children. As Mamta ages, she realizes that her children don’t want her anymore and eventually want to dump her by sending her to an old age home. However, she pleads before them but all her pleas are ignored. That is when Mamta decides to follow her dreams, which she had not fulfilled due to family commitments.