Hum Hain Kamaal Ke is an action comedy drama. The movie revolves around two physically challenged friends - Nilamber (Kader Khan), who is deaf, and Pitamber (Anupam Kher), who is blind. The duo have a good coordination between themselves, and can do anything that a normal person can do, which makes it difficult for others to realize that the two are differently abled. Being confident about their skills, the two decide to solve a murder. However, the question remains, whether the two are as skilled to solve a complicated murder case.