Sikandar is the story of Sanjay Rathod a.k.a Sikandar a.k.a Raja Sahab (Salman Khan), a man with a heart of gold who belongs to the royal family of Rajkot. Raja Sahab helps the destitutes and is happily married to Saisri (Rashmika Mandanna). During a flight from Rajkot from Mumbai, Sanjay beats up a man, Arjun (Prateik Babbar) for misbehaving badly with an actress (Neha Iyer). Arjun turns out to be the son of the Home Minister, Rakesh Pradhan (Sathyaraj) who seethes with rage and deploys a cop, Kishore (Prakash Sudarshan), to nab Sanjay and make his life miserable but the formers attempts turn futile as Sanjay has the support of the locals. An incident in Sanjay's life compells him to move to Mumbai where he comes face to face with the home minister on his home turf. What happens next forms the rest of the film.