Hum Aapke Hain Koun..! is a romantic musical family drama. The movie revolves around Prem (Salman Khan) and Nisha (Madhuri Dixit). Prem and his elder brother Rajesh (Mohnish Behl) lose their parents at an early age, and since then they live with their uncle Kailash (Alok Nath). Rajesh gets married to Pooja (Renuka Shahane) and soon after, she gives birth to a baby boy. Meanwhile, Pooja’s younger sister Nisha and Prem fall in love with each other. However, things take a turn when Pooja meets with an accident and dies an untimely death. Later, Nisha is expected to marry Rajesh, so that her sister’s baby can get the much-needed motherly love. Stuck between her duty and happiness, what will Nisha choose?